Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
|Authors:||Ten Hacken E, Guieze R, Wu CJ|
|Institution:||Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA; Broad Institute, Cambridge, MA, USA.|
|Journal:||Cancer Cell. 2017 Nov 13;32(5):716-716.e1. doi: 10.1016/j.ccell.2017.10.015.|
|Authors:||Ruefli-Brasse A, Reed JC|
|Institution:||Roche, Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland email@example.com. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.|
|Journal:||Biochem J. 2017 Oct 23;474(21):3643-3657. doi: 10.1042/BCJ20170080.|
|Authors:||Chai-Adisaksopha C, Brown JR|
|Institution:||Department of Medicine and. Hamilton, ON, Canada; and. Harvard Medical School, Boston, MA.|
|Journal:||Blood. 2017 Nov 23;130(21):2278-2282. doi: 10.1182/blood-2017-07-731588. Epub 2017 Oct 12.|
|Authors:||Saba NS, Wong DH, Tanios G, Iyer JR, Lobelle-Rich P, Dadashian EL, Liu D, Fontan L, Flemington EK, Nichols CM, Underbayev C, Safah H, Melnick A, Wiestner A, Herman SEM|
|Institution:||Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, Louisiana. Sarah.Herman@nih.gov firstname.lastname@example.org.; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland. Sarah.Herman@nih.gov email@example.com.; Section of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York.; Department of Pathology, Tulane University, New Orleans, Louisiana.|
|Journal:||Cancer Res. 2017 Dec 15;77(24):7038-7048. doi: 10.1158/0008-5472.CAN-17-2485. Epub 2017 Oct 9.|
|Authors:||Gentile M, Petrungaro A, Uccello G, Vigna E, Recchia AG, Caruso N, Bossio S, De Stefano L, Palummo A, Storino F, Martino M, Morabito F|
|Institution:||a Hematology Unit, Department of Hemato-Oncology , Ospedale Annunziata , Cosenza , Italy. , Italy. , Italy. , Italy. Aprigliano , Italy. Aprigliano , Italy. Aprigliano , Italy. Aprigliano , Italy. Aprigliano , Italy. Aprigliano , Italy.|
|Journal:||Expert Opin Investig Drugs. 2017 Nov;26(11):1307-1316. doi: 10.1080/13543784.2017.1386173. Epub 2017 Oct 9.|
|Authors:||Robak P, Robak T|
|Institution:||a Department of Experimental Hematology , Medical University of Lodz , Lodz , Poland.|
|Journal:||Expert Opin Investig Drugs. 2017 Nov;26(11):1249-1265. doi: 10.1080/13543784.2017.1384814. Epub 2017 Oct 3.|
|Authors:||Said R, Tsimberidou AM|
|Institution:||a Department of Oncology , University of Balamand, St. George Hospital University Medical Center , Beirut , Lebanon. Houston , TX , USA. Houston , TX , USA.|
|Journal:||Expert Opin Biol Ther. 2017 Nov;17(11):1463-1470. doi: 10.1080/14712598.2017.1377178. Epub 2017 Sep 11.|
|Authors:||Tripathi R, Lee-Verges E, Higashi M, Gimenez N, Rosich L, Lopez-Guerra M, Colomer D|
|Institution:||a Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hematopathology Unit , Hospital Clinic, CIBERONC , Barcelona , Spain.|
|Journal:||Expert Opin Drug Discov. 2017 Oct;12(10):1041-1052. doi: 10.1080/17460441.2017.1362387. Epub 2017 Aug 4.|
|Authors:||Hansson L, Asklid A, Diels J, Eketorp-Sylvan S, Repits J, Soltoft F, Jager U, Osterborg A|
|Institution:||Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. firstname.lastname@example.org. email@example.com.|
|Journal:||Ann Hematol. 2017 Oct;96(10):1681-1691. doi: 10.1007/s00277-017-3061-3. Epub 2017 Jul 31.|
|Authors:||Albi E, Baldoni S, Aureli P, Dorillo E, Del Papa B, Ascani S, Di Ianni M, Falzetti F, Sportoletti P|
|Institution:||Institute of Hematology, Centro di Ricerche Emato-Oncologiche (CREO), University of Perugia, Perugia - Italy.; Hematology Section, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila - Italy.; Institute of Pathology, Ospedale S. Maria di Terni and University of Perugia, Perugia - Italy.|
|Journal:||Tumori. 2017 Nov 15;103(Suppl. 1):e37-e40. doi: 10.5301/tj.5000667.|
|Authors:||Umit EG, Baysal M, Durmus Y, Demir AM|
|Institution:||Department of Hematology, Faculty of Medicine Trakya University, Edirne, Turkey. Turkey.|
|Journal:||Int J Lab Hematol. 2017 Oct;39(5):552-556. doi: 10.1111/ijlh.12695. Epub 2017 Jun 12.|
|Authors:||Crombie J, Davids MS|
|Institution:||Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Massachusetts.|
|Journal:||Am J Hematol. 2017 Dec;92(12):1393-1397. doi: 10.1002/ajh.24808. Epub 2017 Jul 29.|
|Authors:||Wu Y, Wang Y, Gu Y, Xia J, Kong X, Qian Q, Hong Y|
|Institution:||a Medical Institution Conducting Clinical Trials for Human Used Drug, The Fifth People's Hospital of Shanghai , Fudan University , Shanghai , China.; b Department of General Psychiatry, Shanghai Mental Health Center , Shanghai Jiaotong University , Shanghai , China.; c Department of Hematology, The Fifth People's Hospital of Shanghai , Fudan University , Shanghai , China.; d Department of Osteology, The Fifth People's Hospital of Shanghai , Fudan University , Shanghai , China.|
|Journal:||Hematology. 2017 Dec;22(10):578-584. doi: 10.1080/10245332.2017.1333974. Epub 2017 Jun 3.|
|Authors:||Howard DR, Munir T, McParland L, Rawstron AC, Milligan D, Schuh A, Hockaday A, Allsup DJ, Marshall S, Duncombe AS, O'Dwyer JL, Smith AF, Longo R, Varghese A, Hillmen P|
|Institution:||Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. University of Leeds, Leeds, UK. Leeds, UK. Birmingham, UK. Oxford University Hospital Trust, Oxford, UK. University of Leeds, Leeds, UK. Kingdom and Hull York Medical School, University of Hull, Hull, UK. of Leeds, Leeds, UK. of Leeds, Leeds, UK. of Leeds, Leeds, UK. (LICAP), University of Leeds, Leeds, UK.|
|Journal:||Leukemia. 2017 Nov;31(11):2416-2425. doi: 10.1038/leu.2017.96. Epub 2017 Mar 24.|
|Authors:||Munir T, Howard DR, McParland L, Pocock C, Rawstron AC, Hockaday A, Varghese A, Hamblin M, Bloor A, Pettitt A, Fegan C, Blundell J, Gribben JG, Phillips D, Hillmen P|
|Institution:||Department of Haematology, St James's University Hospital, Leeds, UK. University of Leeds, Leeds, UK. University of Leeds, Leeds, UK. Leeds, UK. University of Leeds, Leeds, UK. Liverpool, UK.|
|Journal:||Leukemia. 2017 Oct;31(10):2085-2093. doi: 10.1038/leu.2017.65. Epub 2017 Apr 20.|
|Authors:||Freise KJ, Jones AK, Menon RM, Verdugo ME, Humerickhouse RA, Awni WM, Salem AH|
|Institution:||Abbvie Inc., North Chicago, IL, USA.|
|Journal:||Hematol Oncol. 2017 Dec;35(4):679-684. doi: 10.1002/hon.2373. Epub 2016 Dec 16.|
|Authors:||Meunier G, Ysebaert L, Nguyen-Thi PL, Lepretre S, Quinquenel A, Dupuis J, Lemal R, Aurran T, Tomowiak C, Cymbalista F, Dilhuydy MS, Brion A, Morel P, Cazin B, Leblond V, Cartron G, Re D, Bene MC, Michallet AS, Feugier P|
|Institution:||Nancy University Hospital, France.|
|Journal:||Hematol Oncol. 2017 Dec;35(4):671-678. doi: 10.1002/hon.2370. Epub 2016 Nov 22.|
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What Our Customers Are Saying...
"I was recently diagnosed with CLL and searched all over the Web for information. I found the MediFocus Guidebook on Chronic Lymphocytic Leukemia to be a very useful resource. The information about chemotherapy was most important to me as well as recent studies concerning general treatments for this condition. The most valuable information was contained in the extensive references listed which were easy to access with a simple 'mouse' click. You are welcome to use my name as a reference."
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